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Jaiswal, Ruby
- Treatment of Myocardial Infarction by Stem Cell Based Therapy
Abstract Views :236 |
PDF Views:66
Authors
Affiliations
1 Krupanidhi College of Pharmacy, Chikkabellandur, Carmelaram, Bangalore - 560 035, Karnataka, IN
1 Krupanidhi College of Pharmacy, Chikkabellandur, Carmelaram, Bangalore - 560 035, Karnataka, IN
Source
Journal of Pharmaceutical Research, Vol 16, No 1 (2017), Pagination: 4-13Abstract
Purpose: Recently myocardial infarction is one of the leading causes of death worldwide. Myocardial infarction leads to the serious consequences which cause increase in mortality and morbidity. In myocardial infarction there is permanent loss of cardiomyocytes which results an irreversible loss of cardiac function. Cardiac repair requires the replacement, restoration and regeneration of heart function. Conventional therapies such as revascularization, percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG) prevent the additional damage to heart muscle and also reduce the risk of future heart attack. However, there is need to develop a new therapy to improve the infracted area after the myocardial infarction and also to lower the mortality rate.
Approaches: The data were collected from various sources like journal articles, internet, textbooks, related materials in library and databases such as Pubmed, Science Direct, Springer, Google Scholar and so on.
Findings: Stem cell-based therapy is found to be a much more promising therapy when compared to other available therapies. Stem cells therapy shows significantly improved heart function after myocardial infarction, therefore decline into heart failure.
Conclusion: Recently the interest is stem cell based therapies which provide the potential benefit and have ability to improve the cardiac function. In this review, we highlight the benefits of stem cells in cardiac repair.
Keywords
Stem Cells, Totipotent, Pluripotent, Multipotent, Myocardial Infarction.Full Text
References
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- A Review on Drug Interactions in Oral Hypoglycemic Drugs by Mechanism of Cytochrome P450 Enzyme Inhibition
Abstract Views :252 |
PDF Views:91
Authors
Affiliations
1 Krupanidhi College of Pharmacy, #12/1, Chikkabellandur, Carmelaram Post, Varthur Hobli , Bangalore - 560035, KA, IN
1 Krupanidhi College of Pharmacy, #12/1, Chikkabellandur, Carmelaram Post, Varthur Hobli , Bangalore - 560035, KA, IN
Source
Journal of Pharmaceutical Research, Vol 16, No 2 (2017), Pagination: 154-159Abstract
Purpose: Drug interaction is a phenomenon that has to be thoroughly investigated in order to avoid adverse effects. This review article highlights the drug interaction of oral hypoglycemics by mechanism of cytochrome P450 enzyme inhibition.
Approach: Published articles from PubMed and other sources were used to review and compile these drug interaction studies.
Findings: Drug interaction in oral hypoglycemics by mechanism of cytochrome P450 enzyme inhibition can increase the risk of hypoglycemia in diabetic patients and hence dose adjustments may be required.
Conclusion: These drug interaction studies are essential for patients suffering from diabetes mellitus as it prevents the risk of occurrence of hypoglycemia. This information is also important for the prescribing physicians as dose alteration or alternate drugs need to administered in case of concomitant administration of drugs in case of polypharmacy.
Keywords
Drug Interaction, CYP450 Enzyme, Oral Hypoglycemics, Food-Drug Interaction.Full Text
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